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Human Interleukin 12b (IL12B)

  • 货 号 GA-PR0015HU
    种 属 Human
    规 格 0.1 mg/0.2mg
    品 牌 GenAsia
    产 地 Shanghai China
    单 价 US$350/US$620
    1,宿主 Host: Nicotiana benthamiana
    2,种类Species: Human
    3,蛋白类型Protein Type: Recombinant
    4,别名Synonyms: Il12, IL-12B, IL-12p40, IL12p40
    5,纯度Purity: 95% by SDS-PAGE
    6, 应用范围Application: WB, Elisa, Functional Studies
    Interleukin-12 (IL-12) is a heterodimer cytokine composed of p40 and p35 subunits. It is mainly produced by macrophages, dendritic cells, and B cells. It has multiple effects on T and natural killer (NK) cells. In particular it appears to be a major factor for the development of cellular immunity. IL-12 stimulates the production and secretion of several cytokines, in particular IFN-gamma, by NK cells and T cells, induces proliferation and enhances the cytotoxic activity within these cell populations. The p40 subunit of IL-12 interacts with the beta subunit of IL-12R and the disulfide linked p40 homodimer specifically antagonize the activity of bioactive IL-12 in different assay systems.
    Avoid repeated freeze and thaw cycle.Store at 2-8℃ for delivery and store at -20 or -70℃ for future use. The loss rate of the target protein which describes the stability was determined by accelerated thermal degradation test.That is to incubate the protein at 37℃ for 48h and no obvious degradation and precipitation were observed.The loss of this protein is less than 5% within the expiration date under appropriate storage condition.